Abstract
To our knowledge, a case of primary oral malignant melanoma (MM) invading mainly the jaw has yet to be reported. We report a case of MM that spread widely in the mandibular medullary cavity with limited involvement of the mucosa. A 40-year-old woman visited our hospital because of mobility of the lower right second molar. Initial examination showed that the second molar floated, and the gingiva was pale purple-blue. An X-ray film showed a diffuse radiolucent area from the premolar to the ramus of the right mandible. The diagnosis of a biopsy specimen was MM, and no distant metastasis was detected on whole body examination. A wide tumor resection with radical neck dissection and immediate reconstruction were performed. Histopathological examination of the specimen revealed MM invading mainly the mandibular bone marrow; however, the primary site remained unknown. DAV-Feron therapy was given postoperatively. Three months later, left cervical lymph node metastasis was detected, and neck dissection was performed. Three years after the first visit, a metastatic lesion in the pleural space was excised by thoracosopic surgery. Ten courses of DAV-Feron therapy were completed, and the patient is now under observation.
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