Abstract
Granulocytic sarcoma (chloroma) is a rare extramedullary lesion of malignant myeloid precursor cells. We report a case of granulocytic sarcoma that developed in the submandibular gland as an extramedullary recurrence of acute myeloid leukemia (AML). A 13-year-old boy was referred to our hospital because of a painful mass in the right submandibular region. Magnetic resonance imaging and computed tomography revealed a 49 × 26 mm mass in the right submandibular region. Acute myeloid leukemia (AML) (WHO) classification AML without maturation, FAB M1) developed 2 years previously, and the patient received chemotherapy, allogeneic bone mallow transplantation (BMT), and donor lymphocyte infusion (DLI). He achieved complete remission for 8 months. A biopsy of this mass yielded a diagnosis of granulocytic sarcoma. The tumor shrank in response to local irradiation (6 Gy). However, the patient died of deterioration of general condition. Because patients with leukemia who have extramedullary recurrence are considered to have a poor prognosis, frequent follow-up is necessary in the future.
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