Abstract
Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine malignancy of the skin. We report a case of MCC of the lower lip. An 85-year-old woman was referred to our hospital because of a tumor in her lower lip. An extraoral examination revealed a palpable soft tumor measuring 17 × 11mm. A malignant tumor was suspected, and a FDG-PET/CT was performed. Accumulation was observed in the lower lip, the first spinous process, the right side of the second vertebral body, the left seventh rib, and the right pubis. The lip was resected first, because it was considered to be a bone metastasis of non-Hodgkin's lymphoma, the treatment of which had been discontinued in the past. A pubic biopsy was performed after surgery and MCC with multiple bone metastases was diagnosed. The painful pubis and ischium were irradiated (30Gy/10fr), and Avelumab and Denosumab administered. However, brain metastasis and irAE enteritis were observed, and the patient died of this disease one year and eight months after the initial diagnosis.
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