Abstract
Publisher Summary This chapter describes the methods and concepts of steroid hormone transport through the blood–brain barrier. The two extracellular fluid compartments in brain are the brain interstitial fluid (ISF) and the cerebrospinal fluid, the latter occupying the four cerebral ventricles and the subarachnoid space. The concentration of exchangeable steroid hormone in brain ISF is potentially amenable to direct in vivo measurement using intracerebral dialysis fibers. The metabolic clearance rate of steroid hormones by brain is computed from the product of the rate of cerebral blood flow (F) times the net extraction (E). The unidirectional transport clearance rate is a function of cerebral blood flow and the unidirectional extraction of steroid hormone by brain.
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