1 S,3 R-ACPD has cataleptogenic effects and reverses MK-801- and less pronounced, d,l-amphetamine-induced locomotion

Abstract

The purpose of this study was to examine the motor effects of (1 S,3 R)-1-amino-cyclopentane-1,3-dicarboxylic acid (1 S,3 R-ACPD), an agonist at metabotropic glutamate receptors, its interaction with dizocilpine (MK-801), a NMDA receptor antagonist, and with d,l-amphetamine, an indirect dopamine receptor agonist. 1 S,3 R-ACPD (20, 30, 40, 80 μg) evoked prominent locomotor and exploratory deficits in an open-field hole-board test and a moderate akinesia and rigidity in a catalepsy test (30, 40, 80 μg). MK-801 (0.08, 0.16, 0.32 mg/kg i.p.) as well as d,l-amphetamine (1.0, 2.0, 3.0 mg/kg i.p.) potently reversed 1 S,3 R-ACPD-induced (80 μg) catalepsy. MK-801 and d,l-amphetamine, administred alone, induced motor stimulation. 1 S,3 R-ACPD (80 μg) reversed the effects of the two lower doses of MK-801. 1 S,3 R-ACPD reversed d,l-amphetamine-induced motor stimulation to a minor extent than that of MK-801. Thus motor deficits induced by 1 S,3 R-ACPD were reversed by both, NMDA receptor blockade and dopamine receptor activation. 1 S,3 R-ACPD reversed motor stimulation, induced by NMDA receptor blockade and, however less pronounced, that by dopamine receptor activation.