1 Oral - Early detection of breast cancer in high-risk women based on longitudinal changes in serum-based proteins: the TESTBREAST study

Abstract

Background: Women who have a high risk of developing breast cancer due to a familial predisposition or mutations in susceptibility genes undergo adapted screening programs. The earlier onset of screening and higher number of screening moments leaves quite a burden on these women, next to that interval cancers can still occur between scheduled screening moments. Therefore, the prospective, multicenter Dutch TESTBREAST study aims to identify a novel panel of blood-based protein biomarkers. Hereby, the aim is to enable early breast cancer detection for high-risk women using a relatively simple blood test to monitor biomarker levels.