Abstract
The aims of the study were to determine the efficacy and safety of long-term maintenance treatment of patients with duodenal ulcer disease with ranitidine. To provide a background against which the results of this study can be judged, a review of the natural history of duodenal ulcer disease is given, together with an account of the influence that surgery and maintenance treatment with H2-receptor antagonists have had on ulcer disease. It is concluded that duodenal ulcer disease constitutes a chronic disposition to develop ulcer recurrence which persists for many decades and that patients with this condition remain at risk of developing haemorrhage, perforation, and pyloric stenosis for many years.
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