Abstract
A new alkaloid, 1-hydroxytropacocaine, was isolated from leaves of greenhouse-cultivated Erythroxylum novogranatense var. novogranatense and identified. Quantitative levels of this alkaloid in dry leaf were similar to those for cocaine, i.e. 0.3–0.5% w/w. 1-Hydroxytropacocaine was also detected at 0.04–0.07% w/w (relative to dry coca leaf) in greenhouse-cultivated Erythroxylum novogranatense var. truxillense and at similar levels in Erythroxylum novogranatense var. novogranatense, grown at a tropical site other than in South America. The presence of 1-hydroxytropacocaine was <0.01% w/w (relative to dry coca leaf) in suspected Erythroxylum novogranatense var. novogranatense and Erythroxylum coca var. coca, field-cultivated in Colombia and Bolivia, respectively.
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