Abstract
Abstract The 1β-hydroxylation of 3α,17α,20β,21-tetrahydroxy-5β-pregnan-11-one was shown to occur in vivo in a man and in vitro by surviving liver slices of the guinea pig. The position and configuration of the metabolically introduced hydroxyl group were determined by chemical degradation and by nuclear magnetic resonance spectroscopy. This hydroxylation also was observed, but to a much smaller extent, when 3α,17α,21-trihydroxy-5β-pregnane-11,20-dione and 5β-pregnane-3α,17α,20α-triol were administered to the same subject.
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