Abstract
We investigated the correlation of the soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) with markers of cardiovascular disease in subjects with normal glucose tolerance (NGT) and 1 h postload glucose ≥155 mg/dL after an oral glucose tolerance test. We stratified 282 subjects without a previous diagnosis of diabetes into three groups: 123 controls (NGT and 1 h postload glycemia <155 mg/dL), 84 NGT and 1 h postload glycemia ≥155 mg/dL (NGT 1 h high), and 75 subjects with impaired fasting glucose and/or impaired glucose tolerance (IFG/IGT). NGT 1 h high subjects exhibited lower esRAGE (0.36 ± 0.18 vs. 0.4 5 ± 0.2, p < 0.05) and higher S100A12 levels than controls (5684 (3193.2–8295.6) vs. 3960.1 (2101.8–7419), p < 0.05). Furthermore, they showed an increased pulse wave velocity (PWV) and intima–media thickness (IMT). No differences were found between the NGT 1 h high group and the IFG/IGT group regarding cardiometabolic profiles. After multiple regression analyses, esRAGE was associated with glycated hemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP). Age, HbA1c, and esRAGE were the determinants of IMT, whereas S100A12 and systolic pressure were the determinants of PWV. The NGT 1 h high group exhibited low esRAGE levels and an altered cardiometabolic profile. HbA1c, S100A12, and hs-CRP were associated with these alterations. In conclusion, subjects with NGT are not a homogeneous population, and they present different cardiovascular and glycometabolic risks.
Highlights
Prediabetes, a common disorder of glucose homeostasis, is prevalent in the general population, and affected subjects are at high risk of progression to overt diabetes and cardiovascular disease [1,2].As such, prediabetes typically represents three groups of individuals: those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT), and those with a glycated hemoglobin (HbA1c ) between 5.7% and 6.4% (39–46 mmol/mol) [3]
normal glucose tolerance (NGT) 1 h high subjects were older than the controls but were similar with regard to body mass index (BMI), Waist circumference (WC), total cholesterol, systolic Blood pressure (BP), and diastolic BP
Subjects with impaired fasting glucose and/or impaired glucose tolerance (IFG/IGT) were similar to NGT 1 h high with respect to anthropometric and metabolic characteristics except for age, fasting glucose, 1 and 2 h postload glucose, HbA1c, and HOMA-IR (Table 1)
Summary
Prediabetes, a common disorder of glucose homeostasis, is prevalent in the general population, and affected subjects are at high risk of progression to overt diabetes and cardiovascular disease [1,2].As such, prediabetes typically represents three groups of individuals: those with impaired fasting glucose (IFG), those with impaired glucose tolerance (IGT), and those with a glycated hemoglobin (HbA1c ) between 5.7% and 6.4% (39–46 mmol/mol) [3]. Prediabetes, a common disorder of glucose homeostasis, is prevalent in the general population, and affected subjects are at high risk of progression to overt diabetes and cardiovascular disease [1,2]. Reliable models for identification of individuals at high risk for future type 2 diabetes are essential and have important clinical implications for intervention programs [7]. 155 mg/dL (8.6 mmol/L) at 1 h during an oral glucose tolerance test (OGTT) can identify adults at increased risk for future development of type 2 diabetes among those who have normal glucose tolerance (NGT 1 h high) [8,9,10]. It has been demonstrated that subjects with NGT 1 h high showed an unfavorable cardiometabolic profile similar to that observed in individuals with IGT
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
