Abstract
This chapter examines the research carried out on the dynein motor protein reflecting its role in the life of a cell. It describes how Ian Gibbons, as the first person of his family to attend a university, participated in discovering the properties of this fascinating and extremely complex protein, dynein motor protein. Describing Ian’s experiences at Cambridge and Harvard, it throws light on how Ian, along with other scientists, came about the discovery of dynein protein and its characteristics. The results of the discovery are described in the form of diagrams and tables in the chapter. Furthermore, it gives an overview of the protein chemistry of dynein protein, revealing its complexity. The study of dyneins came about as a revolution in cell biology and revealed various isoforms of dynein in the process. Also, properties like dynein’s microtubule binding domain and cycling of dynein ATPase were understood. Following this, the chapter discusses the process of transition from protein chemistry to molecular biology, throwing light on the sequencing of DNA coding and experimental assay of nucleotide-binding to beta and gamma heavy chain subunits of outer-arm dynein. Finally, the chapter describes studies on bend initiation, growth, and propagation of dynein protein, also throwing light on some areas of research on dynein protein yet to be explored.
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