Year-end Sale % OFF 
Abstract
1-Deoxynojirimycin (DNJ, C6H13NO4, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and Commelina communis (dayflower) as well as from several bacterial strains such as Bacillus and Streptomyces species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.
Highlights
Polyhydroxylated piperidines and their derivatives are famous for their excellent bioactivities [1].Iminosugars contain an analog of pyranose ring or D-glucose, in which the ring oxygen atom is replaced by a nitrogen atom. 1-Deoxyiminosugars are chemically more stable than normal iminosugars because of absence of a hydroxyl group at the C1 position
The iminosugars contain an analog of pyranose ring or D-glucose, in which the ring oxygen atom is replaced by a nitrogen atom. 1-Deoxyiminosugars are chemically more stable than normal iminosugars because of absence of a hydroxyl group at the C1 position
Reduction of nojirimycin led to the chemical synthesis of DNJ [3]; afterward, DNJ was found from natural source, i.e., mulberry tree root [4]
Summary
Polyhydroxylated piperidines and their derivatives are famous for their excellent bioactivities [1]. To the rapid growth of bioactivity databases, in silico target fishing approaches and accessible web Currently, the prediction of biological targets of small drug molecules has become very easy owing services [36]. The output data methods are appropriate to the drug-like small organic entities, which induce biological effects but of these approaches are validated by adopting useful modality. Methods are appropriate small organic whichthe induce biological effects the aimtoofthe thisdrug-like detailed review article isentities, to summarize existing knowledge on but haveoccurrence, ambiguousextraction, macromolecular targets purification, determination, chemistry, and bioactivities of DNJ, so that the the use aimit of this detailed review article is to summarize the existing researchers may to explore future perspectives of research on DNJ. 2. 1-Deoxynojirimycin targets of DNJ will be investigated using suitable in silico approach
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
