Abstract
1-Cyanoacetyl-3,5-dimethylpyrazole (1) is a white crystalline solid with a melting point of 118–121 °C,[1] stable at room temperature in air. In the 1950s, Ried and Meyer[1] were the first to describe it as a mild cyanoacetylating reagent, being more reactive than ethyl cyanoacetate. Pyrazole 1 is a cheap, handy, and non-toxic reagent that proved to be superior to cyanoacetyl chloride and cyanoacetyl azide in terms of stability and convenience. It is commercially available and can be prepared in about 90% yield by condensation of acetylacetone (2) with cyanoacetohydrazide (3) in aqueous hydrochloric acid (Scheme [1]).[2]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
