Abstract
The crystal structure of the title compound, C30H38N2O5Si, has been investigated to establish the relative stereochemistry at the spiro ring junction and the two anomeric centres. Each of the O atoms in the tetrahydropyran rings adopts an axial position on the neighbouring ring. This bis-diaxial conformation is adopted, thus gaining maximum stablization from the anomeric effect. The silyl-protected hydroxymethyl and uracil substituents adopt equatorial positions on their associated tetrahydropyran rings, thereby minimizing unfavourable steric interactions. The dimeric (2′R*,6′R*,8′R*)- and (2′S*,6′S*,8′S*)-uridine units are connected to each other across crystallographic inversion centres via intermolecular N—H⋯O hydrogen bonds.
Highlights
Crystal dataR factor = 0.053; wR factor = 0.111; data-to-parameter ratio = 16.4
The crystal structure of the title compound, C30H38N2O5Si, has been investigated to establish the relative stereochemistry at the spiro ring junction and the two anomeric centres
Each of the O atoms in the tetrahydropyran rings adopts an axial position on the neighbouring ring
Summary
R factor = 0.053; wR factor = 0.111; data-to-parameter ratio = 16.4. The crystal structure of the title compound, C30H38N2O5Si, has been investigated to establish the relative stereochemistry at the spiro ring junction and the two anomeric centres. Each of the O atoms in the tetrahydropyran rings adopts an axial position on the neighbouring ring. This bis-diaxial conformation is adopted, gaining maximum stablization from the anomeric effect. The silyl-protected hydroxymethyl and uracil substituents adopt equatorial positions on their associated tetrahydropyran rings, thereby minimizing unfavourable steric interactions. The dimeric (20 R*,60 R*,80 R*)and (2 S*,6 S*,8 S*)-uridine units are connected to each other across crystallographic inversion centres via intermolecular
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More From: Acta Crystallographica Section E Structure Reports Online
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