1,8-Cineole an Underappreciated Anti Inflammatory Therapeutic

Abstract

The use of plant-based medicines, health products, food supplements, and cosmetics is being increased nowadays due to their active and healthy ingredients. 1,8-cineole is a natural monoterpene, also known as eucalyptol. It is a major compound of many plant essential oils, mainly extracted from Eucalyptus globulus, Elettaria cardamom, Amomum subulatum Roxb. 1,8-cineole has recently been identified as a rhizosphere volatile in Arabidopsis, is well known as an allelopathic agent from Salvia and Artemisia. These are traditionally used as herbal medicine in Ayurveda, Homeopathy, Naturopathy, Siddha, Unani and Yoga worldwide. They are indigenous plant native to India and are rich in bioactive molecules like alkaloids, anthocyanins, chlorogenic acids, coumarins, flavonoids, lignans, phenolic acids, saponins and glycosidic substitutes, tannins and terpenoids. Hence they are used to cure a wide range of diseases and act as a good anti-diabetic agent. 1,8-Cineole is a colourless liquid and found is many medicinal plants. This review aims to summarize the pharmacological bio-activities reported in literature. A system review was collected from various public databases such as NCBI, EMBASE and other reported research articles. Methodologies were focused on 1,8-Cineole anti-inflammatory property, gastroprotective mechanism, anti-microbial property, Anti-proliferative and Hepatoprotective mechanism. The present review aims to summarize and consolidate the biological properties of 1,8-Cineole.