Abstract
The title compound, C19H22N4O3S, comprises a thienopyridine moiety which is characteristic for antiplatelet agents of the clopidogrel class of compounds. In the crystal, inversion dimers are formed through pairs of C—H⋯O interactions. The benzene ring plane and the nitro plane are almost coplanar, with a dihedral angle of 0.83 (2)°. The piperazine ring adopts a chair conformation.
Highlights
The title compound, C19H22N4O3S, comprises a thienopyridine moiety which is characteristic for antiplatelet agents of the clopidogrel class of compounds
Inversion dimers are formed through pairs of C—HÁ Á ÁO interactions
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: KP2278)
Summary
Key indicators: single-crystal X-ray study; T = 113 K; mean (C–C) = 0.002 A; R factor = 0.032; wR factor = 0.088; data-to-parameter ratio = 17.0. The title compound, C19H22N4O3S, comprises a thienopyridine moiety which is characteristic for antiplatelet agents of the clopidogrel class of compounds. Inversion dimers are formed through pairs of C—HÁ Á ÁO interactions. The benzene ring plane and the nitro plane are almost coplanar, with a dihedral angle of 0.83 (2). The piperazine ring adopts a chair conformation. Related literature For background to the bioactivity and applications of the antiplatelet agent clopidogrel, see, for example: Muller et al (2003); Savi et al (1994); Sharis et al (1998). For the synthesis of other derivatives with thienopyridine, see: Cheng (2009)
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