1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)- l-iditol. A new chiral ligand for asymmetric hydrogenation with rhodium complexes as catalysts

Abstract

A new chiral 1,4-diphosphine, 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)- l-iditol, has been prepared from d-mannitol. Rhodium complexes of this ligand are asymmetric homogeneous hydrogenation catalysts for dehydroamino acids, giving ( S)-amino acids in 21–58% optical yields.