1,4,2-Dioxazole synthesis by the reaction of nitrosocarbonyl compounds with 2,5-dimethylfuran

Abstract

Oxidation of hydroxamic acids in the presence of 2,5-dimethylfuran gives excellent yields of the 3-substituted-5-methyl-5-(cis-3-oxobutenyl)-1,4,2-dioxazoles (2); the reaction is reversible and probably occurs by way of an initially formed Diels–Alder adduct.