1.30 Sex Differences in Cerebral Blood Flow Among Adolescents With Bipolar Disorder

Abstract

Developmental sex differences in cerebral blood flow (CBF) may be implicated in the female predominance [2:1; female (F) to male (M) ratio] of bipolar disorder (BD) in adolescence. In childhood, CBF declines in both sexes and then increases mid-adolescence in females; it continues to decline and then plateau in males. For the first time, we examined sex differences in CBF across adolescents with BD vs. healthy control (HC) subjects.