Abstract
Abstract 1,3-Dipolar cycloaddition reaction-based diversity-oriented synthesis developed from our research lab is highlighted. The initial [3 + 2] cycloaddition products are subjected to postcondensation modifications to afford heterocyclic scaffolds with substitutional, skeletal, and stereochemical variations. Multicomponent reactions and fluorous linker-facilitated separation are integrated to increase the efficiency of compound library synthesis.
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