Abstract
A series of novel 1,3-dioxoindan-2-carboxamide-based complexes were synthesized, designed to employ both the attributes of half-sandwich complexes and the topoisomerase inhibiting properties of the ligand scaffold. The compounds were characterized with standard analytical methods. Their stability in aqueous systems and the impact of either the metal center or the ligand scaffold on the affinity toward small biomolecules such as amino acids, DNA model compounds, and small proteins were determined by IT-ESI mass spectrometry. The cytotoxicity was investigated in three human cancer cell lines by means of a colorimetric MTT assay, and preliminary structure–activity relationships were derived. The benzyl derivatives showed the highest in vitro activity and promising topoisomerase IIα inhibition in the range of the IC50 values. In addition, the induced changes in the cell cycle distribution were determined and the apoptosis induction potential elucidated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
