Abstract
The work was funded by: Researchers Supporting Project at King Saud University (RSP-2020/50) (Saudi Arabia); National Research Foundation (NRF) and the University of KwaZulu-Natal (South Africa); the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) (RTI2018-093831-B-100), CIBER-BBN, and the Generalitat de Catalunya (2017 SGR 1439) (Spain). Rotimi Sheyi thanks to MINTEK for a predoctoral fellowship.
Highlights
Introduction sTriazine derivatives have found numerous applications due to their potential to show biological and therapeutic activity
The general rule for the replacement of these chlorine atoms, which varies with the reactivity of the nucleophile used, proposes that the first substitution occurs at 0 °C, the second at room temperature and the third under heating conditions (Scheme 1).[17]
Using TCT as the starting material, the derivatives were synthesized by sequentially substituting its chlorine atoms with an equivalent amount of the three different nucleophile(s)
Summary
Introduction sTriazine derivatives have found numerous applications due to their potential to show biological and therapeutic activity. The ability of various nucleophiles to substitute the chlorine atoms in TCT makes this reagent suitable for the preparation of mono-, di- and trisubstituted derivatives of 1,3,5-triazine in a controlled manner.[12,13,14,15,16]
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