Abstract
We have studied the effects of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2D 3) on bone mass and bone mineral appositional rate in intact rats and rats with inflammation-mediated osteopenia (IMO), where osteoblast number and mineral appositional rate are decreased. 1,25(OH) 2D 3 prevents IMO-specific bone loss when given in a daily dose of 25 ng per rat, but does not when given in higher doses. The hormone was effective, when given over the complete duration of the experiment (21 days), but not when given over shorter time periods (7 and 14 days, respectively). 1,25(OH) 2D 3 prevents IMO-dependent reduction in mineral appositional rate and leads to an only moderate increase in intact rats. We conclude, that 1,25(OH) 2D 3 is more effective in stimulating mineral appositional rate in rats with IMO where mineral apposition is impaired.
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