Abstract
Using the CuAAC reaction as a key step, a novel series of Nilotinib analogues was prepared by replacing the imidazole ring in the Nilotinib molecule with 1,2,3-triazole moiety via a divergent synthetic approach. The synthesized compounds were tested for cytotoxic activity against a series of tumor cell lines which included U251, PC-3, K562, HCT-15, MCF-7 and SKLU. Inhibition growth up to 85.6 % was observed for some compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
