1-[1-(trans-4-Isopropylcyclohexyl)piperidin-4-yl]indolin-2-one, one of a novel series of nociceptin receptor ligands

Abstract

The title compound, C22H32N2O, is a member of the family of nociceptin receptor ligands derived from N-(4-piperidinyl)-2-indolinones. Modifications of the piperidine N-substituent can produce both agonists and antagonists, with the title compound being a weak agonist. The mol­ecule lies on a crystallographic mirror plane.