1,1′-Binaphthylazepine-based ligands for the enantioselective dialkylzinc addition to aromatic aldehydes

Abstract

The new 1,1′-binaphthylazepine ligand 1c has been prepared and tested in the enantioselective addition of Et 2Zn to arylaldehydes, allowing us to reach ee’s up to 97% and giving extremely rapid reactions (10–20 min). Aminoalcohol 1c and the analogous compounds 1a and 1b were then tested in the enantioselective addition of Bu 2Zn and Me 2Zn to arylaldehydes. All of the ligands efficiently catalyze the Bu 2Zn addition to benzaldehyde, providing good yields in short reaction times (2–4 h) and high ee (up to 96%). In the enantioselective methylation of arylaldehydes ligands 1b and 1c gave high yields (88–97%) and good to high (80–90%) ee’s.