1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a reusable promoting medium for the catalyst-free and green synthesis of dihydropyrano[2,3-c]pyrazole scaffolds

Abstract

A manufactured protocol that is both helpful and free of catalyst has been presented for the production of dihydropyrano[2,3-c]pyrazole frameworks in polyfluorinated alcohol as a reusable promoting medium. All reactions are completed quickly, and the products are obtained in astounding yields. Notably, the convenient approach has remarkable yields, avoids the use of hazardous solvents or reagents, is simple to operate, and only requires one pot. The 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was extremely stable and could be repeated four times without significant basic alteration or action, making it ideal for large-scale and organic production.