Abstract
The effect of 1-germatranol hydrate, compared to trekrezan, on protein synthesis and the related systems regulating the development, differentiation, regeneration and maintenance of both cellular and tissue homeostasis was studied in vitro using the human peripheral blood mononuclear cells (PBMC) culture. The activating effect of 1-germatranol hydrate on the total activity of tryptophanyl-tRNA synthetase, one of the key enzymes in the extraribosomal stage of the tryptophanyl-tRNA synthetase protein synthesis, is shown. A 15 μg / ml dose of 1-germatranol hydrate increases the expression of tryptophanyl-tRNA synthetase by 33-45% more than a 15 μg / ml dose of trecrezan. By stimulating the biosynthesis of immunoglobulins, germatranol hydrate exhibits an actoprotective effect, thus accelerat-ing the formation of both forms of aminoacyl tRNA synthetase. Activated tryptophanyl-tRNA synthetase, suppressing pathological processes of abnormal aggressive proliferation of blood vessels, stimulates the restorative physiological development of blood vessels. The data obtained suggest that 1-germatranol hydrate can be used as a pharmaceutical exhibiting immunomodulatory and adaptogenic action.
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