Abstract
Epidermal resident memory CD8+ T cell (TRM) provide efficient host defense against neoplasia and pathogens. After antigen-driven expansion in lymph node, differentiation of T cell effectors into TRM and their persistence in the epidermis is independent of cognate antigen but requires TGFβ. TRM that do encounter cognate antigen in the skin outcompete ‘bystander’ TRM that do not encounter antigen in the skin by unknown mechanisms. We examined the effect of antigen encounter in the skin by comparing Ova-specific OT-I TRM recruited to skin by Vaccinia virus-Ova (VV-Ova) infection where antigen is present with ‘bystander’ TRM recruited by epicutaneous application of the chemical sensitizer DNFB at a different site within the same animal.
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