Abstract

The formation of complex stratified epithelial barriers in mammals is essential for animal survival. During mouse embryonic development the skin epithelium is generated from a simple single-layered epithelium which stratifies and differentiates to form a multi-layered epidermis just before birth. But the mechanisms underlying epidermal stratification and how cells switch their cell fate from basal to suprabasal cells are still unknown. Recently, we proposed a two-phase model of epidermal stratification, with the first major phase starting around embryonic day E13.5 when the epithelium gets multi-layered.

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