Abstract
The strategy of fluid resuscitation in severe sepsis and septic shock is a matter of ever-ongoing debate. Current sepsis guidelines recommend albumin in patients requiring large amounts of crystalloids for circulatory stability. Although the same guidelines also recommend bolus administration of fluid, concerns have been raised that fluid boluses might lead to increased extravasation of albumin leading to sustained tissue edema in patients with sepsis-induced activation of the systemic inflammatory response.
Highlights
septic shock is a matter of ever-ongoing debate
concerns have been raised that fluid boluses might lead to increased extravasation
of albumin leading to sustained tissue edema in patients
Summary
The strategy of fluid resuscitation in severe sepsis and septic shock is a matter of ever-ongoing debate. Current sepsis guidelines recommend albumin in patients requiring large amounts of crystalloids for circulatory stability. The same guidelines recommend bolus administration of fluid, concerns have been raised that fluid boluses might lead to increased extravasation of albumin leading to sustained tissue edema in patients with sepsis-induced activation of the systemic inflammatory response
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