Abstract
Cutaneous basal (BCC) and squamous cell carcinomas (SCC) are the most commonly occurring cancers in humans. These skin cancers are driven by DNA damage to the epidermis, the body’s outermost protective barrier. Our previous studies demonstrate that DNA damaging agents activate inflammasome signaling in dermal fibroblasts, which enhances epithelial cell proliferation and plasticity in wild-type epidermis, characteristics that are associated with tumorigenesis. Strikingly, however, the role of dermal fibroblasts in cutaneous skin cancer development has not been adequately addressed.
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