0932 RETROSPECTIVE POLYSOMNOGRAPHIC DATA REVIEW OF PERIODIC LIMB MOVEMENTS IN SLEEP IN CHILDREN WITH SICKLE CELL DISEASE AND ITS EFFECTS ON SLEEP

Abstract

Approximately 1 out of every 365 African-American children is born with sickle cell disease (SCD). According to (Rogers et al., 2011), 15 out of 64 (23.4%) children with SCD are also diagnosed with periodic limb movements in sleep (PLMS). The current study aims to assess the prevalence rate of PLMS in a large inner city of pediatric SCD population. In addition, the study will examine the effect of PLMS has on the sleep architecture for this population. The current study is a retrospective chart review. Children between the ages of 2 to 18 with the diagnosis of SCD who underwent a sleep study from January 2005 to December 2015 at Children’s National Health System were included in the study. Subjects with a periodic limb movement index (PLMI) ≥ 5/h were included in the PLMS group. In total, there were 230 patient records that were included for data analysis. Out of those, 103 (44.8%) were male. Average age of participants was 9.3 years. When analyzing PLMS prevalence, there were 52 (22.6%) patients who had PLMS. In addition, 21 (9.1%) of patients had increased leg movements but did not meet criteria for PLMS. Although not significant, there was a notable difference in decreased total sleep time in the PLMS group. Children in the PLMS group had significantly lower stage 3 sleep time percentage (p=0.03), sleep efficacy (p=0.04) and NREM sleep time percentage (p=0.04). PLMS group also had most leg movements in sleep stage 1. The current study was able to increase the power statistic of the prevalence rate of PLMS in children diagnosed with SCD, by replicating previous study findings with a larger sample size. In addition, our results demonstrated that increased pediatric limb movement also had more sleep disruption in children diagnosed with SCD. N/A