092 Subtype-dependent differences in genomic profiles of acral and cutaneous melanoma

Abstract

Acral melanoma is commonly diagnosed in people of color and has worse prognosis than cutaneous melanoma, even when controlling for tumor stage. Here, we seek to assess differences in tumor mutational profiles of acral and cutaneous melanomas, which could potentially impact prognosis and treatment outcomes. Mutational profiles of 1273 melanoma patients (118 acral and 1155 cutaneous) from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (v10.0) were examined by melanoma subtype (acral or cutaneous) and tumor stage (primary or metastatic).