Abstract

The physical damage inflicted by blast waves is called primary blast injury, and lungs are vulnerable to blast waves [1]. Blast lung injuries (BLI) can be extremely critical during the super-acute phase, and hypotension is supposed to be the main cause of death (1) , but its etiology has not been elucidated. Recent studies have demonstrated that hypotension is mediated by the absence of vasoconstriction [2]. However, research investigated the effectiveness of catecholamine for BLI during the super-acute phase was not identified.

Highlights

  • The physical damage inflicted by blast waves is called primary blast injury, and lungs are vulnerable to blast waves [1]

  • The present study aimed to establish a small-animal model of severe Blast lung injuries (BLI) using laser-induced shock wave (LISW) and to evaluate the effect of catecholamine on the super-acute phase of severe BLI

  • Study 2 evaluated the effects of catecholamines as follows

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Summary

Introduction

The physical damage inflicted by blast waves is called primary blast injury, and lungs are vulnerable to blast waves [1]. Blast lung injuries (BLI) can be extremely critical during the super-acute phase, and hypotension is supposed to be the main cause of death (1), but its etiology has not been elucidated. Recent studies have demonstrated that hypotension is mediated by the absence of vasoconstriction [2]. Research investigated the effectiveness of catecholamine for BLI during the superacute phase was not identified

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