Abstract
The cadherin Dsg2 plays critical roles in cell growth and survival and is up-regulated in many cancers including skin and head and neck. We recently showed that Dsg2 down-regulates the tumor suppressor, miR-146a, and up-regulates the pro-inflammatory chemokine, IL-8. Furthermore, Dsg2 enhances small extracellular vesicle (sEV) release, which serve as a carrier of IL-8 on their surface potentially for receptor transactivation. In this study, bulk RNAseq analysis of HNSCC tumor biopsies from patients treated with the PD-1 inhibitor, nivolumab, revealed that Dsg2 was significantly higher in HPV (+) as compared to HPV(-) patients before treatment and was down-regulated in response to treatment.
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