Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. Emerging evidence suggests that homeoproteins can act as modulators of tumor initiation and progression in cSCC. DLX3 is a homeobox transcription factor which plays pivotal roles in embryonic development and epidermal homeostasis. Previous work from our lab, using both human samples and a Dlx3 knock-out (Dlx3cKO) mouse model, demonstrated DLX3’s tumor suppressive role in epithelial tumor development and tumor progression.
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