087 Predictive factors for maintenance of efficacy after cessation of testosterone treatment

Abstract

For patients with testosterone deficiency (TD), there is no conclusive evidence whether discontinuation of treatment is possible or treatment must continue for the rest of lives. If there is a way to maintain efficacy of TRT after cessation of treatment, the potential risks associated with TRT could be reduced. Therefore, predictive factors for maintenance of efficacy of TRT after stopping treatment were investigated in this study. From 2011 to 2016, among 720 hypogonadal patients, 151 men in whom TRT was effective and who were available for follow-up over 6 months after the discontinuation of TRT were included in this study. The type of TRT was consisted of oral testosterone undecanoate (TU), testosterone gel, injection of testosterone enanthate, and injection of TU. Baseline serum total testosterone (TT) levels, the highest TT levels during TRT, and the recent TT levels at 6 months after discontinuation of TRT were investigated with the patients′ medical records including age, body mass index (BMI), waist circumference (WC), comorbidities, life styles, period and type of TRT. Maintenance of response was determined by the recent serum TT levels and the answer of patients to global assessment question about the TD symptoms compared with the baseline