Abstract
Lithium-related neurological toxicity may be severe resulting in seizures, myoclonic encephalopathy, and coma. Three different poisoning presentations exist in humans, including acute poisoning in non-previously treated patients (A), acute-on-chronic poisoning (A/C), and therapeutic overdose (T). The exact reasons why severity and features are different between these three presentations are unknown, although differences in brain lithium distribution have been suggested.
Highlights
Lithium-related neurological toxicity may be severe resulting in seizures, myoclonic encephalopathy, and coma
Lithium pharmacokinetics in the rat according to the three different modalities of human poisoning
Intensive Care Medicine Experimental 2014 2(Suppl 1):P65
Summary
Our objective was to study lithium pharmacokinetics in blood and brain in rat models corresponding to each human presentation
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