Abstract
A possible future influenza A pandemic similar to the 1918 H1N1 outbreak remains an existential public health threat. A universal influenza A vaccine that protects regardless of hemagluttinin (H) and neuraminidase (N) subgroups remains elusive. The influenza genome encodes for a few proteins highly conserved among all flu strains, including NP and M1. We sought to generate a T cell vaccine broadly protective against all influenza A viruses based on this property. Using Modified Vaccinia Ankara (MVA), we created MVA-NP and MVA-M1 vectors.
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