0832 ABOUT CLOCKS, SLEEP, PAIN AND THEIR INTERACTIVE ROLE IN TMJ OSTEOARTHIRIS - A CASE REPORT

Abstract

Abstract Introduction As a major cause of disability among older people, Temporomandibular Joint Osteoarthritis (OA) remain a critical issue for both geriatric medicine and public health. While etiologic foundations of this condition are still unclear, it is well known that 24h-driven biological (circadian) rhythms are basic physiological requirements for the homeostatic control of peripheral tissues, such as skeletal muscle, bone and particularly cartilage. Sleep, as the most conspicuous circadian rhythm rooling health and welbeing, is also relevant for anabolic and catabolic processes within cartilage, with nocturnal sleep regulating other factors from which depend important metabolic pathways . Pain, which is chronically coupled to OA is not only impacted by both circadian rhythms and sleep but is itself a contributor to circadian misalignment and sleep disruption which therefore increase pain propensity maintaining a deleterious vicious cycle. Hence, knowledge on such interactive structural and functional composition should be of great relevance both for preventing and successfully treating this chronic, debilitating, neurodegenerative disorder. Methods Authors are reporting an interesting case of a patient in which circadian disruption, impaired sleep and exacerbated persistent pain co-ocur within OA. Sleep questionnaires (Insomnia Severity Index - ISI, STOP-BANG Results NA Conclusion From this singular case, a chronobiological approach (phototherapy) directed to circadian alignment and sleep improvement showed to be effective both for general clinical improvement and for its long-term prognosis associated to OA. Support (if any)