Abstract
Low-intensity shockwave therapy (LiST) is safe and efficacious in men with vasculogenic erectile dysfunction(ED). There is lack of data however, on the safety and efficacy of different energy levels and session frequency per week. This study compares the safety and efficacy of different LiST protocols for vasculogenic ED. Two different energy flux density (EFD) and two different session frequencies are investigated. 96 patients were randomized into 4 groups. All patients received a total of 12 LiST sessions: Group A received LiST twice a week with EFD of 0.05mJ/mm2; Group B received LiST three times a week with EFD of 0.05mJ/mm2; Group C received LiST twice a week with EFD of 0.10mJ/mm2; Group D received LiST three times a week with EFD of 0.10mJ/mm2. Sessions were delivered within a 4 week (Groups B, D) or 6 week (Groups A, C) period, without any break in treatment. IIEF-EF domain score, Minimally Clinical Important Differences (MCID), and Sexual Encounter Profile question 3 (SEP3) assessed subjective erectile function; objective assessment of penile hemodynamics was based on Peak Systolic Velocity (PSV).
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