078 Transcript profiling for TSLP in human squamous cell carcinoma in situ

Abstract

SCCIS (squamous cell carcinoma in situ) is a precursor lesion for cSCC which is the second most common cancer in the US. Research on immunoediting and immune evasion has identified potential mechanisms that highly-mutated SCCIS cells use to avoid immunosurveillance. However, little is known about how SCCIS cells acquire immune evasive properties. Our recent work suggests that UV-exposed keratinocytes that form SCCIS attain immune evasive properties during lesion development. First, our whole Exome-seq studies identified UV-signature loss-of-function mutations in NOTCH1-3 in the epidermis and known oncogenic mutations in TP53 in SCCIS.