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Abstract
Impaired testosterone production as a result of Leydig cell loss or dysfunction can occur in men with testicular failure. Although several testosterone formulations are available, none are capable of replicating the physiological pattern of testosterone secretion. We have shown in our recent study conducted in murine models that, Leydig stem cell transplantation along with peritubular myoid cells and Sertoli cells could be used to physiologically increase serum testosterone thereby potentially minimizing the adverse effects. However, in order to optimize the function of Leydig stem cells, we need to understand the paracrine factors released by myoid and Sertoli cells. In the present study we evaluated the significance of paracrine factors secreted by human peritubular myoid cells and Sertoli cells on Leydig stem cell function. A total of 5 men with testicular failure underwent testis biopsies for sperm retrieval. Using an IRB approved protocol, about 10mg of testicular tissue from each of these men were processed for Leydig stem cell isolation, culture and characterized.
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