Abstract
Skin commensals have been suggested to have a role in the pathogenesis of atopic dermatitis (AD), and bacteriotherapy has attracted attention. Here, we investigated the bacterial dynamics of AD patients treated by bleach baths and identified 13 bacterial species as candidates for biotherapy. Skin swab samples were collected monthly from AD patients for 6 months before and after 3-month bleach baths and analyzed using 16S rRNA gene sequencing. Multiple regression analysis using objective SCORing AD (o-SCORAD) and 34 representative bacterial species revealed that two bacterial species, Staphylococcus aureus and Staphylococcus hominis, were positively correlated with o-SCORAD, while 13 species of bacteria were inversely correlated.
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