075 A STUDY ON ACUTE KIDNEY INJURY FOLLOWING CARDIAC SURGERY (AKICS) – PRELIMINARY DATA: A SINGLE CENTER EXPERIENCE

Abstract

Epidemiology and Outcomes from AKI Dr JER MING LOW Up to 30% of cardiac surgery patients developed some form of acute kidney injury (AKI) where AKI has been associated with morbidity, mortality and longer hospitalization. This study aims to determine the incidence of AKI following cardiac surgery in our center and to identify possible contributing risk factors to the development of AKI. This is a single centered prospective observational study where all patients who underwent open cardiac surgery in Hospital Tengku Ampuan Afzan from 1 April 2017 to 31 March 2018 will be enrolled. Patient’s demographic and relevant clinical data were retrieved from medical records. Baseline creatinine, 24 and 48 hours value will be recorded. All patients were then classified into AKI or non-AKI group based on AKIN classification. Nineteen patients were enrolled in this preliminary data. Mean age of patients were 54.7 (10.9) years old. Five (26.3%) patients have underlying chronic kidney disease (CKD) and 7 (36.8%) patients have diabetes mellitus. Sixteen (84.2%) subjects underwent coronary artery bypass graft (CABG) while the remaining had valve replacement surgery. Nine (47.4%) patients developed AKI where 2 (10.5%) required haemodialysis support. The mean preoperative and 48-hour postoperative creatinine level was 116 (48)μmol/L and 156 (89)μmol/L respectively. There was no significant difference between age, gender, comorbid disease, types of surgery, IABP, baseline blood investigation level, hematocrit level, cardiopulmonary bypass (CPB) and aortic cross clamping (AXC) time with the development of AKI. The incidence of AKI in this preliminary data approximately 47%, which is higher compared to other international data. Interestingly in this preliminary result, we found no significant associations between CPB and AXC time with development of AKI despite these risk factors are known to be associated with AKI. However, our sample size in this preliminary data is too small but we hope that with further extension of this study and incoming data, we will be able to clarify the real incidence of AKI and to identify risk factors to development of AKI.