Abstract
BP180 is a hemidesmosomal protein in the skin and other epithelial tissues. The extracellular domain NC16A of BP180 is the main target of pathogenic autoantibodies in bullous pemphigoid (BP). Anti-BP180 autoantibodies exist in both the sera and cerebrospinal fluids of patients with dementia or stroke, suggesting that BP180 could be a shared autoantigen of the skin and brain. The purpose of this study was to investigate the expression of BP180 in the brain and whether BP180 in the brain is the same as skin in mice.
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