Abstract
The use of cardiovascular drugs increased in recent years [1], including the use of β-blockers, such as metoprolol. And although the β-blockade is still very contradictory in patients with sepsis, both studies in experimental models and in septic patients with previous prescription of β-blockers have shown a potential role of these drugs in patients with sepsis [2, 3].
Highlights
The use of cardiovascular drugs increased in recent years [1], including the use of b-blockers, such as metoprolol
Twenty pigs in which septic shock was induced through intravenous E. coli infusion (6x109 c.f.u/kg in 2h) were randomly assigned (n=10 per group) to the Metoprolol group (214.2 μg kg-1 of metoprol infused in 45 minutes) or Control group, which received a correspondent volume of normal saline
Blood samples obtained at baseline, T120 and T360, were analyzed for cytokines (tumor-necrosis factor (TNF)alpha, interleukin (IL)-1beta, IL-6 and IL-10), troponin I (TNNI) and B-type natriuretic peptide (BNP) using commercial ELISA kits
Summary
To evaluate the effect of metoprolol, a beta 1 selective beta-blocker, over echocardiographic parameters, cytokines and cardiac markers, in a porcine model of septic shock
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