0732. Sequential changes in the pattern of liver architecture in the acute phase of severe sepsis under the vision of videomicroscopy. Experimental study

Ihj Koh,Jc Vieirra,Rc Tedesco,J Almeida-Filho,Ama Liberatore,Rb Souza

doi:10.1186/2197-425x-2-s1-p54

Abstract

Therapeutic grounded in the specific state of microcirculatory dysfunction in septic patients is still an impediment due to technological limitations, and consequently there is little knowledge about the pathophysiological microcirculatory dynamics associated with organ failure.

Highlights

Therapeutic grounded in the specific state of microcirculatory dysfunction in septic patients is still an impediment due to technological limitations, and there is little knowledge about the pathophysiological microcirculatory dynamics associated with organ failure
At SDF-images is possible to visualize the hexagonal architecture of hepatic lobules with radiated sinusoidal blood flow draining into the central lobular vein between the columns of hepatocytes, showing the close interaction between microcirculation and hepatocytes
Already since 30min (T30, T1) merges areas with enlargement of hepatocytes with dilated sinusoids and narrowing of sinusoids, suggesting broad cellular edema and sinusoids that make up those narrowed blood flow limitation

Summary

Introduction

Therapeutic grounded in the specific state of microcirculatory dysfunction in septic patients is still an impediment due to technological limitations, and there is little knowledge about the pathophysiological microcirculatory dynamics associated with organ failure

Methods

Results

Conclusions