Abstract
Sepsis-induced lung injury is one of the major causes of morbidity and mortality in intensive care patients [1]. The clinical manifestations include pulmonary hypertension, formation of extravascular lung water (EVLW), and deterioration of pulmonary gas exchange. Administration of sildenafil, a selective inhibitor of isoenzyme phosphodiesterase-5, in patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension [2].
Highlights
Sepsis-induced lung injury is one of the major causes of morbidity and mortality in intensive care patients [1]
Twenty anesthetized and mechanically ventilated pigs were randomized after baseline (BL) measurements to Control or Sildenafil (100mg) group
After 30 minutes of saline/sildenafil administration, all animals were submitted to a continuous lipopolysaccharide (LPS) infusion (4mcg/kg/min) until the end of study
Summary
To evaluate the effect of sildenafil on endotoxin-induced lung injury in pigs
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